PATIENT BENEFITS
•    Helps defend against UVR and formation of free radicals
•    Boosts skin immunity
•    Promotes firmer skin tone and softer texture
•    Reduces the appearance of fine lines
•    Improves translucency
•    Helps fade pigmentation and unclog pores
•    Aids moisturisation

NEED TO KNOW

• This item can only be delivered to addresses in New Zealand and Australia. 

PRODUCT USAGE

•    Use sparingly in the morning.
•    2 – 3 drops is sufficient for the entire face.
•    A tingling sensation may occur on application, due to the low pH of the product. This normally disappears after 30 – 60 seconds.

THE SERUM
•    Rejuvenating Serum consists of clinically-established concentrations of anti-oxidant vitamins A, C, and E in a propylene glycol serum base.
•    As a category, anti-oxidant vitamins help to defend skin against free radicals which are generated during exposure to UV radiation and other environmental aggressors such as pollution. They can also improve skin function and reduce signs of photoageing.
•    Rejuvenating Serum is in a propylene glycol base which improves penetration into the stratum corneum and creates an anaerobic environment to keep the product stable.
•    pH of Rejuvenating Serum is 2.8. Low pH (<3.5) is considered essential in L-ascorbic acid products for dermal penetration and efficacy.  Due to the acidity of this formulation, some patients will notice a tingling or prickling sensation on application. This quickly subsides.
•    Vitamins A,C & E work synergistically both in the skin and in this serum to prevent oxidation & degradation of vitamin potency.    VITAMIN C (L-ascorbic acid)
•    Vitamin C occurs naturally in the skin as a result of dietary intake. As a result of intrinsic and photo ageing, dietary intake does not result in optimal levels of Vitamin C in the skin. Naturally-present Vitamin C is degraded by UV radiation and reactive oxygen species.
•    Studies with cultured fibroblasts indicate a strong increase in collagen synthesis after exposure to ascorbate.  Vitamin C stimulates the production of collagen in the skin, ameliorating structure and firming skin tone.
•    L-ascorbic acid is an excellent free radical scavenger, preventing formation of DNA lesions and visbile signs of  ageing. In vitro studies show strong cytoprotective qualities for Vitamin C.
•    High dosage Vitamin C may improve the performance of skin lightening products and procedures. In vitro studies have shown the ability of ascorbic acid to interfere in melanin synthesis.

VITAMIN A (Retinol)
•    Topically-delivered retinol is capable of being metabolised into retinaldehyde and retinoic acid (tretinoin) according to theoretical models.
•    Retinoic acid is also associated with reversal of photo-ageing, causing improvement in epidermal thickness, dysplasia, keratoses and collagen production.
•    Clinically, retinol seems to elicit these same anti-photoageing effects. The mechanism for this is not yet known.
•    Retinol is effective in fading pigmentation as it accelerates exfoliation of melanised keratinocytes.
•    Retinol assists with cellular differentiation and exfoliation by promoting cleavage of corneocytes from the stratum corneum.
•    Retinoic acid is demonstrated to be effective in acne therapy due to its ability to normalise cellular shedding inside individual sebaceous follicles. It is possible that retinol helps to improve acne by this same mechanism.

VITAMIN E (Tocopherol acetate)
•    Tocopherol acetate has been demonstrated to provide protection against UV damage, including erythema and edema.
•    Clinical studies suggest that the combination of Vitamins E and C is more effective than either vitamin applied singly in providing photo-protection. Added vitamin A completes the vitamin antioxidant profile.

                          

INGREDIENTS:
Water (S), Propylene Glycol (S), Glycerine, L-Ascorbic Acid (A), L-lysine, L-Retinol (A), Sweet Orange Oil (M), Tocopherol Acetate (A).

Codebreaker: A=antioxidant, S=solvent, M=moisturiser.

EXPLANATIONS
Propylene Glycol    Solvent for anti-oxidants. Offers excellent percutaneous absorption as well as preventing oxidisation of anti-oxidants.

Sweet Orange Oil    Moisturiser and fragrance agent.


CONTRAINDICATIONS
Pregnancy    Toxicity of vitamin A dosage in this formulation in pregnancy is unknown. Use of this product is not recommended during pregnancy.